Acinic Cell Carcinoma (AciCC)

Basophilic granular cytoplasm (zymogen granules), DOG1+, NR4A3-related.
Secretory carcinoma has eosinophilic/vacuolated cytoplasm, S100+/mammaglobin+, DOG1–.

Mucoepidermoid Carcinoma (MEC)

Adenoid Cystic Carcinoma (ACC)

Pleomorphic Adenoma

Mixed epithelial + myoepithelial components with chondromyxoid stroma; PLAG1/HMGA2 alterations.
Secretory carcinoma shows uniform epithelial differentiation with secretions.

Low-grade Cribriform Adenocarcinoma of the Tongue

Distinct site (oropharyngeal tongue base), S100+/SOX10+, but lacks ETV6-NTRK3 fusion and lacks eosinophilic intraluminal secretions.

Malignant salivary gland lesions

Pathologies